Binding of estrogenic compounds to recombinant estrogen receptor-[alpha]: application to environmental analysis

Binding of estrogenic compounds to recombinant estrogen receptor-[alpha]: application to environmental analysis
Balaguer, Patrick
3/1/2005
Environmental Health Perspectives
Estrogenic activity in environmental samples could be mediated through a wide variety of compounds and by various mechanisms. High-affinity compounds for estrogen receptors (ERs), such as natural or synthetic estrogens, as well as low-affinity compounds such as alkylphenols, phthalates, and polychlorinated biphenyls are present in water and sediment samples. Furthermore, compounds such as polycyclic aromatic hydrocarbons, which do not bind ERs, modulate estrogen activity by means of the aryl hydrocarbon receptor (AhR). In order to characterize compounds that mediate estrogenic ...
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